Ontology highlight
ABSTRACT:
SUBMITTER: Mardinly AR
PROVIDER: S-EPMC5970968 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Mardinly Alan R AR Oldenburg Ian Antón IA Pégard Nicolas C NC Sridharan Savitha S Lyall Evan H EH Chesnov Kirill K Brohawn Stephen G SG Waller Laura L Adesnik Hillel H
Nature neuroscience 20180430 6
Understanding brain function requires technologies that can control the activity of large populations of neurons with high fidelity in space and time. We developed a multiphoton holographic approach to activate or suppress the activity of ensembles of cortical neurons with cellular resolution and sub-millisecond precision. Since existing opsins were inadequate, we engineered new soma-targeted (ST) optogenetic tools, ST-ChroME and IRES-ST-eGtACR1, optimized for multiphoton activation and suppress ...[more]