Ontology highlight
ABSTRACT:
SUBMITTER: Fang F
PROVIDER: S-EPMC5970969 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Fang Fang F Angulo Benjamin B Xia Ninuo N Sukhwani Meena M Wang Zhengyuan Z Carey Charles C CC Mazurie Aurélien A Cui Jun J Wilkinson Royce R Wiedenheft Blake B Irie Naoko N Surani M Azim MA Orwig Kyle E KE Reijo Pera Renee A RA
Nature cell biology 20180430 6
Dysregulation of genetic pathways during human germ cell development leads to infertility. Here, we analysed bona fide human primordial germ cells (hPGCs) to probe the developmental genetics of human germ cell specification and differentiation. We examined the distribution of OCT4 occupancy in hPGCs relative to human embryonic stem cells (hESCs). We demonstrated that development, from pluripotent stem cells to germ cells, is driven by switching partners with OCT4 from SOX2 to PAX5 and PRDM1. Gai ...[more]