Rapidity of Correction of Hyponatremia Due to Syndrome of Inappropriate Secretion of Antidiuretic Hormone Following Tolvaptan.

ABSTRACT:

Background

Tolvaptan effectively corrects hyponatremia due to the syndrome of inappropriate secretion of antidiuretic hormone (SIADH), but undesired overcorrection can occur. We hypothesized that pretherapy parameters can predict the rapidity of response to tolvaptan in SIADH.

Study design

Multicenter historical cohort study.

Setting & participants

Adults with SIADH or congestive heart failure (CHF) treated with tolvaptan for a serum sodium concentration ≤ 130 mEq/L at 5 US hospitals.

Predictors

Demographic and laboratory parameters.

Outcomes

Rate of change in serum sodium concentration.

Measurements

Spearman correlations, analysis of variance, and multivariable linear mixed-effects models.

Results

28 patients with SIADH and 39 patients wit

SUBMITTER: Morris JH 

PROVIDER: S-EPMC5970971 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature