Dataset Information

Outdoor air pollution and mosaic loss of chromosome Y in older men from the Cardiovascular Health Study.

ABSTRACT: BACKGROUND:Mosaic loss of chromosome Y (mLOY) can occur in a fraction of cells as men age, which is potentially linked to increased mortality risk. Smoking is related to mLOY; however, the contribution of air pollution is unclear. OBJECTIVE:We investigated whether exposure to outdoor air pollution, age, and smoking were associated with mLOY. METHODS:We analyzed baseline (1989-1993) blood samples from 933 men ?65?years of age from the prospective Cardiovascular Health Study. Particulate matter ?10??m (PM10), carbon monoxide, nitrogen dioxide, sulfur dioxide, and ozone data were obtained from the U.S. EPA Aerometric Information Retrieval System for the year prior to baseline. Inverse-distance weighted air monitor data were used to estimate each participants' monthly residential exposure. mLOY was detected with standard methods using signal intensity (median log-R ratio (mLRR)) of the male-specific chromosome Y regions from Illumina array data. Linear regression models were used to evaluate relations between mean exposure in the prior year, age, smoking and continuous mLRR. RESULTS:Increased PM10 was associated with mLOY, namely decreased mLRR (p-trend?=?0.03). Compared with the lowest tertile (?28.5??g/m3), the middle (28.5-31.0??g/m3; ??=?-0.0044, p?=?0.09) and highest (?31??g/m3; ??=?-0.0054, p?=?0.04) tertiles had decreased mLRR, adjusted for age, clinic, race/cohort, smoking status and pack-years. Additionally, increasing age (??=?-0.00035, p?=?0.06) and smoking pack-years (??=?-0.00011, p?=?1.4E-3) were associated with decreased mLRR, adjusted for each other and race/cohort. No significant associations were found for other pollutants. CONCLUSIONS:PM10 may increase leukocyte mLOY, a marker of genomic instability. The sample size was modest and replication is warranted.

SUBMITTER: Wong JYY

PROVIDER: S-EPMC5971001 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature

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Outdoor air pollution and mosaic loss of chromosome Y in older men from the Cardiovascular Health Study.

Wong Jason Y Y JYY Margolis Helene G HG Machiela Mitchell M Zhou Weiyin W Odden Michelle C MC Psaty Bruce M BM Robbins John J Jones Rena R RR Rotter Jerome I JI Chanock Stephen J SJ Rothman Nathaniel N Lan Qing Q Lee Jennifer S JS

Environment international 20180424

<h4>Background</h4>Mosaic loss of chromosome Y (mLOY) can occur in a fraction of cells as men age, which is potentially linked to increased mortality risk. Smoking is related to mLOY; however, the contribution of air pollution is unclear.<h4>Objective</h4>We investigated whether exposure to outdoor air pollution, age, and smoking were associated with mLOY.<h4>Methods</h4>We analyzed baseline (1989-1993) blood samples from 933 men ≥65 years of age from the prospective Cardiovascular Health Study. ...[more]

PMID: 29698900

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Project description:OBJECTIVES:Outdoor air pollution is a serious environmental problem worldwide. Current systematic reviews (SRs) and meta-analyses (MAs) mostly focused on some specific health outcomes or some specific air pollution. DESIGN:This evidence gap map (EGM) is to identify existing gaps from SRs and MAs and report them in broad topic areas. DATA SOURCES:PubMed, Cochrane, Scopus and Web of Science were searched from their inception until June 2018. Citations and reference lists were traced. ELIGIBILITY CRITERIA:SRs and MAs that investigated the impact of outdoor air pollution on human health outcomes were collected. This study excluded original articles and qualitative review articles. DATA EXTRACTION AND SYNTHESIS:Characteristics of the included SRs and MAs were extracted and summarised. Extracted data included authors, publication year, location of the corresponding author(s), publication journal discipline, study design, study duration, sample size, study region, target population, types of air pollution and health outcomes. RESULTS:Asia and North America published 93% of SRs and MAs included in this EGM. 31% of the SRs and MAs (27/86) included primary studies conducted in 5-10 countries. Their publication trends have increased during the last 10 years. A total of 2864 primary studies was included. The median number of included primary studies was 20 (range, 7-167). Cohort studies, case cross-over studies and time-series studies were the top three most used study designs. The mostly researched population was the group of all ages (46/86, 53%). Cardiovascular diseases, respiratory diseases and health service records were mostly reported. A lack of definite diagnostic criteria, unclear reporting of air pollution exposure and time period of primary studies were the main research gaps. CONCLUSIONS:This EGM provided a visual overview of health outcomes affected by outdoor air pollution exposure. Future research should focus on chronic diseases, cancer and mental disorders.

Project description:BackgroundHigher exposure to outdoor air pollution is associated with increased cardiopulmonary deaths, but there is limited evidence about the association between outdoor air pollution and diagnosed cardiovascular disease. Our study aimed to estimate the size of the association between long term exposure to outdoor air pollution and prevalent cardiovascular disease.MethodsWe carried out a cross-sectional analysis of data on more than 19,000 white adults aged 45 and older who participated in three representative surveys of the English population in 1994, 1998 and 2003, examining the relationship between self-reported doctor-diagnosed cardiovascular disease and exposure to outdoor air pollutants using multilevel regression techniques and meta-analysis.ResultsThe combined estimates suggested that an increase of 1 microg m-3 in concentration of particulate matter less than 10 microns in diameter was associated with an increase of 2.9% (95% CI -0.6% to 6.5%) in prevalence of cardiovascular disease in men, and an increase of 1.6% (95%CI -2.1% to 5.5%) in women. The year-specific analyses showed strongly positive associations in 2003 between odds of cardiovascular disease in both men and women and exposure to particulate matter but not in 1994 or 1998. We found no consistent associations between exposure to gaseous air pollutants and doctor-diagnosed cardiovascular disease.ConclusionThe associations of prevalent cardiovascular disease with concentration of particulate matter less than 10 microns in diameter, while only weakly positive, were consistent with the effects reported in cohort studies. The results provide evidence of the size of the association between particulate air pollution and the prevalence of cardiovascular disease but no evidence for an association with gaseous pollutants. We found strongly positive associations between particulate matter and cardiovascular disease in 2003 only, which highlights the importance of replicating findings in more than one population.

Project description:BackgroundOutdoor air pollution is a major threat to global public health that needs responsible participation of researchers at all levels. Assessing research output is an important step in highlighting national and international contribution and collaboration in a certain field. Therefore, the aim of this study was to analyze globally-published literature in outdoor air pollution - related respiratory health.MethodOutdoor air pollution documents related to respiratory health were retrieved from Scopus database. The study period was up to 2017. Mapping of author keywords was carried out using VOSviewer 1.6.6.ResultsSearch query yielded 3635 documents with an h-index of 137. There was a dramatic increase in the number of publications in the last decade of the study period. The most frequently encountered author keywords were: air pollution (835 occurrences), asthma (502 occurrences), particulate matter (198 occurrences), and children (203 occurrences). The United States of America ranked first (1082; 29.8%) followed by the United Kingdom (279; 7.7%) and Italy (198; 5.4%). Annual research productivity stratified by income and population size indicated that China ranked first (22.2) followed by the USA (18.8). Analysis of regional distribution of publications indicated that the Mediterranean, African, and South-East Asia regions had the least contribution. Harvard University (92; 2.5%) was the most active institution/organization followed the US Environmental Protection Agency (89; 2.4%). International collaboration was restricted to three regions: Northern America, Europe, and Asia. The top ten preferred journals were in the field of environmental health and respiratory health. Environmental Health Perspective was the most preferred journal for publishing documents in outdoor pollution in relation to respiratory health.ConclusionResearch on the impact of outdoor air pollution on respiratory health had accelerated lately and is receiving a lot of interest. Global research networks that include countries with high level of pollution and limited resources are highly needed to create public opinion in favor of minimizing outdoor air pollution and investing in green technologies.

Dataset Information

Outdoor air pollution and mosaic loss of chromosome Y in older men from the Cardiovascular Health Study.

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Outdoor air pollution and mosaic loss of chromosome Y in older men from the Cardiovascular Health Study.

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