Ontology highlight
ABSTRACT:
SUBMITTER: Sun J
PROVIDER: S-EPMC5971442 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Sun Jian J Hu Qianwen Q Peng Hong H Peng Cheng C Zhou Liheng L Lu Jinsong J Huang Chuanxin C
The Journal of biological chemistry 20180406 21
Connexin-43 (Cx43, also known as GJA1) is the most ubiquitously expressed connexin isoform in mammalian tissues. It forms intercellular gap junction (GJ) channels, enabling adjacent cells to communicate both electrically and metabolically. Cx43 is a short-lived protein which can be quickly degraded by the ubiquitin-dependent proteasomal, endolysosomal, and autophagosomal pathways. Here, we report that the ubiquitin-specific peptidase 8 (USP8) interacts with and deubiquitinates Cx43. USP8 reduces ...[more]