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Spread of Clonally Related Escherichia coli Strains Harboring an IncA/C1 Plasmid Encoding IMP-8 and Its Recruitment into an Unrelated MCR-1-Containing Isolate.

ABSTRACT: Ten IMP-8-producing Escherichia coli isolates were recovered from surveillance cultures of a neonatal intensive care unit; eight of the isolates were clonally related. A 168.2-kb blaIMP-8 plasmid was fully sequenced, and it corresponded to the recently described IncA/C1-ST13 plasmid. This plasmid was detected in all isolates, even in those that were not clonally related. One unrelated isolate was also resistant to colistin and positive for mcr-1 This marker was located in a 62.7-kb IncI2 plasmid, which was also fully sequenced.

SUBMITTER: Elena A

PROVIDER: S-EPMC5971582 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature

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Spread of Clonally Related Escherichia coli Strains Harboring an IncA/C1 Plasmid Encoding IMP-8 and Its Recruitment into an Unrelated MCR-1-Containing Isolate.

Elena Alan A Cejas Daniela D Magariños Francisco F Jewtuchowicz Virginia V Facente Andrea A Gutkind Gabriel G Di Conza José J Radice Marcela M

Antimicrobial agents and chemotherapy 20180525 6

Ten IMP-8-producing Escherichia coli isolates were recovered from surveillance cultures of a neonatal intensive care unit; eight of the isolates were clonally related. A 168.2-kb blaIMP-8 plasmid was fully sequenced, and it corresponded to the recently described IncA/C1-ST13 plasmid. This plasmid was detected in all isolates, even in those that were not clonally related. One unrelated isolate was also resistant to colistin and positive for mcr-1 This marker was lo ...[more]

PMID: 29661868

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