Ontology highlight
ABSTRACT:
SUBMITTER: Chavez-Jacobo VM
PROVIDER: S-EPMC5971611 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Chávez-Jacobo Víctor M VM Hernández-Ramírez Karen C KC Romo-Rodríguez Pamela P Pérez-Gallardo Rocío Viridiana RV Campos-García Jesús J Gutiérrez-Corona J Félix JF García-Merinos Juan Pablo JP Meza-Carmen Víctor V Silva-Sánchez Jesús J Ramírez-Díaz Martha I MI
Antimicrobial agents and chemotherapy 20180525 6
The pUM505 plasmid, isolated from a clinical <i>Pseudomonas aeruginosa</i> isolate, confers resistance to ciprofloxacin (CIP) when transferred into the standard <i>P. aeruginosa</i> strain PAO1. CIP is an antibiotic of the quinolone family that is used to treat <i>P. aeruginosa</i> infections. <i>In silico</i> analysis, performed to identify CIP resistance genes, revealed that the 65-amino-acid product encoded by the <i>orf131</i> gene in pUM505 displays 40% amino acid identity to the <i>Mycobac ...[more]