Dental pulp stem cell-derived chondrogenic cells demonstrate differential cell motility in type I and type II collagen hydrogels.

ABSTRACT: BACKGROUND CONTEXT:Advances in the development of biomaterials and stem cell therapy provide a promising approach to regenerating degenerated discs. The normal nucleus pulposus (NP) cells exhibit similar phenotype to chondrocytes. Because dental pulp stem cells (DPSCs) can be differentiated into chondrogenic cells, the DPSCs and DPSCs-derived chondrogenic cells encapsulated in type I and type II collagen hydrogels can potentially be transplanted into degenerated NP to repair damaged tissue. The motility of transplanted cells is critical because the cells need to migrate away from the hydrogels containing the cells of high density and disperse through the NP tissue after implantation. PURPOSE:The purpose of this study was to determine the motility of DPSC and DPSC-derived chondrogenic cells

SUBMITTER: Yao L 

PROVIDER: S-EPMC5972055 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature