Ontology highlight
ABSTRACT:
SUBMITTER: Baraniak I
PROVIDER: S-EPMC5972559 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Baraniak Ilona I Kropff Barbara B McLean Gary R GR Pichon Sylvie S Piras-Douce Fabienne F Milne Richard S B RSB Smith Colette C Mach Michael M Griffiths Paul D PD Reeves Matthew B MB
The Journal of infectious diseases 20180501 12
The human cytomegalovirus (HCMV) virion envelope protein glycoprotein B (gB) is essential for viral entry and represents a major target for humoral responses following infection. Previously, a phase 2 placebo-controlled clinical trial conducted in solid organ transplant candidates demonstrated that vaccination with gB plus MF59 adjuvant significantly increased gB enzyme-linked immunosorbent assay (ELISA) antibody levels whose titer correlated directly with protection against posttransplant virem ...[more]