Ontology highlight
ABSTRACT:
SUBMITTER: Ligat G
PROVIDER: S-EPMC5972660 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Ligat G G Cazal R R Hantz S S Alain S S
FEMS microbiology reviews 20180301 2
Human cytomegalovirus (HCMV) is responsible for life-threatening infections in immunocompromised individuals and can cause serious congenital malformations. Available antivirals target the viral polymerase but are subject to cross-resistance and toxicity. New antivirals targeting other replication steps and inducing fewer adverse effects are therefore needed. During HCMV replication, DNA maturation and packaging are performed by the terminase complex, which cleaves DNA to package the genome into ...[more]