Dataset Information

Alcohol intake in relation to non-fatal and fatal coronary heart disease and stroke: EPIC-CVD case-cohort study.

ABSTRACT:

Objective

To investigate the association between alcohol consumption (at baseline and over lifetime) and non-fatal and fatal coronary heart disease (CHD) and stroke.

Design

Multicentre case-cohort study.

Setting

A study of cardiovascular disease (CVD) determinants within the European Prospective Investigation into Cancer and nutrition cohort (EPIC-CVD) from eight European countries.

Participants

32?549 participants without baseline CVD, comprised of incident CVD cases and a subcohort for comparison.

Main outcome measures

Non-fatal and fatal CHD and stroke (including ischaemic and haemorrhagic stroke).

Results

There were 9307 non-fatal CHD events, 1699 fatal CHD, 5855 non-fatal stroke, and 733 fatal stroke. Baseline alcohol intake was inversely associated with non-fatal CHD, with a hazard ratio of 0.94 (95% confidence interval 0.92 to 0.96) per 12 g/day higher intake. There was a J shaped association between baseline alcohol intake and risk of fatal CHD. The hazard ratios were 0.83 (0.70 to 0.98), 0.65 (0.53 to 0.81), and 0.82 (0.65 to 1.03) for categories 5.0-14.9 g/day, 15.0-29.9 g/day, and 30.0-59.9 g/day of total alcohol intake, respectively, compared with 0.1-4.9 g/day. In contrast, hazard ratios for non-fatal and fatal stroke risk were 1.04 (1.02 to 1.07), and 1.05 (0.98 to 1.13) per 12 g/day increase in baseline alcohol intake, respectively, including broadly similar findings for ischaemic and haemorrhagic stroke. Associations with cardiovascular outcomes were broadly similar with average lifetime alcohol consumption as for baseline alcohol intake, and across the eight countries studied. There was no strong evidence for interactions of alcohol consumption with smoking status on the risk of CVD events.

Conclusions

Alcohol intake was inversely associated with non-fatal CHD risk but positively associated with the risk of different stroke subtypes. This highlights the opposing associations of alcohol intake with different CVD types and strengthens the evidence for policies to reduce alcohol consumption.

SUBMITTER: Ricci C

PROVIDER: S-EPMC5972779 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Alcohol intake in relation to non-fatal and fatal coronary heart disease and stroke: EPIC-CVD case-cohort study.

Ricci Cristian C Wood Angela A Muller David D Gunter Marc J MJ Agudo Antonio A Boeing Heiner H van der Schouw Yvonne T YT Warnakula Samantha S Saieva Calogero C Spijkerman Annemieke A Sluijs Ivonne I Tjønneland Anne A Kyrø Cecilie C Weiderpass Elisabete E Kühn Tilman T Kaaks Rudolf R Sánchez Maria-Jose MJ Panico Salvatore S Agnoli Claudia C Palli Domenico D Tumino Rosario R Engström Gunnar G Melander Olle O Bonnet Fabrice F Boer Jolanda M A JMA Key Timothy J TJ Travis Ruth C RC Overvad Kim K Verschuren W M Monique WMM Quirós J Ramón JR Trichopoulou Antonia A Papatesta Eleni-Maria EM Peppa Eleni E Iribas Conchi Moreno CM Gavrila Diana D Forslund Ann-Sofie AS Jansson Jan-Håkan JH Matullo Giuseppe G Arriola Larraitz L Freisling Heinz H Lassale Camille C Tzoulaki Ioanna I Sharp Stephen J SJ Forouhi Nita G NG Langenberg Claudia C Saracci Rodolfo R Sweeting Michael M Brennan Paul P Butterworth Adam S AS Riboli Elio E Wareham Nick J NJ Danesh John J Ferrari Pietro P

BMJ (Clinical research ed.) 20180529

<h4>Objective</h4>To investigate the association between alcohol consumption (at baseline and over lifetime) and non-fatal and fatal coronary heart disease (CHD) and stroke.<h4>Design</h4>Multicentre case-cohort study.<h4>Setting</h4>A study of cardiovascular disease (CVD) determinants within the European Prospective Investigation into Cancer and nutrition cohort (EPIC-CVD) from eight European countries.<h4>Participants</h4>32 549 participants without baseline CVD, comprised of incident CVD case ...[more]

PMID: 29844013

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Dataset Information

Alcohol intake in relation to non-fatal and fatal coronary heart disease and stroke: EPIC-CVD case-cohort study.

Objective

Design

Setting

Participants

Main outcome measures

Results

Conclusions

Publications

Alcohol intake in relation to non-fatal and fatal coronary heart disease and stroke: EPIC-CVD case-cohort study.

Similar Datasets

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