Ontology highlight
ABSTRACT:
SUBMITTER: Wright DJ
PROVIDER: S-EPMC5973269 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Wright Daniel J DJ Day Felix R FR Kerrison Nicola D ND Zink Florian F Cardona Alexia A Sulem Patrick P Thompson Deborah J DJ Sigurjonsdottir Svanhvit S Gudbjartsson Daniel F DF Helgason Agnar A Chapman J Ross JR Jackson Steve P SP Langenberg Claudia C Wareham Nicholas J NJ Scott Robert A RA Thorsteindottir Unnur U Ong Ken K KK Stefansson Kari K Perry John R B JRB
Nature genetics 20170327 5
The Y chromosome is frequently lost in hematopoietic cells, which represents the most common somatic alteration in men. However, the mechanisms that regulate mosaic loss of chromosome Y (mLOY), and its clinical relevance, are unknown. We used genotype-array-intensity data and sequence reads from 85,542 men to identify 19 genomic regions (P < 5 × 10<sup>-8</sup>) that are associated with mLOY. Cumulatively, these loci also predicted X chromosome loss in women (n = 96,123; P = 4 × 10<sup>-6</sup>) ...[more]