Ontology highlight
ABSTRACT:
SUBMITTER: Lim SY
PROVIDER: S-EPMC5973480 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Lim So-Yon SY Osuna Christa E CE Hraber Peter T PT Hesselgesser Joe J Gerold Jeffrey M JM Barnes Tiffany L TL Sanisetty Srisowmya S Seaman Michael S MS Lewis Mark G MG Geleziunas Romas R Miller Michael D MD Cihlar Tomas T Lee William A WA Hill Alison L AL Whitney James B JB
Science translational medicine 20180501 439
Antiretroviral therapy (ART) can halt HIV-1 replication but fails to target the long-lived latent viral reservoir. Several pharmacological compounds have been evaluated for their ability to reverse HIV-1 latency, but none has demonstrably reduced the latent HIV-1 reservoir or affected viral rebound after the interruption of ART. We evaluated orally administered selective Toll-like receptor 7 (TLR7) agonists GS-986 and GS-9620 for their ability to induce transient viremia in rhesus macaques infec ...[more]