Ontology highlight
ABSTRACT:
SUBMITTER: Ma W
PROVIDER: S-EPMC5973834 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Ma Wen W Whitley Kevin D KD Chemla Yann R YR Luthey-Schulten Zaida Z Schulten Klaus K
eLife 20180417
Helicases play key roles in genome maintenance, yet it remains elusive how these enzymes change conformations and how transitions between different conformational states regulate nucleic acid reshaping. Here, we developed a computational technique combining structural bioinformatics approaches and atomic-level free-energy simulations to characterize how the <i>Escherichia coli</i> DNA repair enzyme UvrD changes its conformation at the fork junction to switch its function from unwinding to rezipp ...[more]