Ontology highlight
ABSTRACT:
SUBMITTER: Savitskaya A
PROVIDER: S-EPMC5974015 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Savitskaya Anna A Nishiyama Akihito A Yamaguchi Takehiro T Tateishi Yoshitaka Y Ozeki Yuriko Y Nameta Masaaki M Kon Tomohiro T Kaboso Shaban A SA Ohara Naoya N Peryanova Olga V OV Matsumoto Sohkichi S
Scientific reports 20180529 1
The architecture of the genome influences the functions of DNA from bacteria to eukaryotes. Intrinsically disordered regions (IDR) of eukaryotic histones have pivotal roles in various processes of gene expression. IDR is rare in bacteria, but interestingly, mycobacteria produce a unique histone-like protein, MDP1 that contains a long C-terminal IDR. Here we analyzed the role of IDR in MDP1 function. By employing Mycobacterium smegmatis that inducibly expresses MDP1 or its IDR-deficient mutant, w ...[more]