Ontology highlight
ABSTRACT:
SUBMITTER: Castellano G
PROVIDER: S-EPMC5974049 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Castellano Giuseppe G Franzin Rossana R Stasi Alessandra A Divella Chiara C Sallustio Fabio F Pontrelli Paola P Lucarelli Giuseppe G Battaglia Michele M Staffieri Francesco F Crovace Antonio A Stallone Giovanni G Seelen Marc M Daha Mohamed R MR Grandaliano Giuseppe G Gesualdo Loreto L
Frontiers in immunology 20180523
Pericytes are one of the principal sources of scar-forming myofibroblasts in chronic kidneys disease. However, the modulation of pericyte-to-myofibroblast transdifferentiation (PMT) in the early phases of acute kidney injury is poorly understood. Here, we investigated the role of complement in inducing PMT after transplantation. Using a swine model of renal ischemia/reperfusion (I/R) injury, we found the occurrence of PMT after 24 h of I/R injury as demonstrated by reduction of PDGFRβ<sup>+</sup ...[more]