Dataset Information

Solute Carrier Family 30 Member 8 Gene 807C/T Polymorphism and Type 2 Diabetes Mellitus in the Chinese Population: A Meta-Analysis Including 6,942 Subjects.

ABSTRACT: Although solute carrier family 30 (zinc transporter) member 8 (SLC30A8) gene 807C/T polymorphism is associated with an increased risk of type 2 diabetes mellitus (T2DM) risk, there remains some inconsistency between individual studies.The aim of the study is to explore the relationship between SLC30A8 gene 807C/T polymorphism and T2DM in the Chinese population.The current meta-analysis compiles and analyzes the data of 6,942 participants from 10 independent studies. Either a fixed or random-effects model was adopted to evaluate the pooled odds ratio (ORs) and the corresponding 95% confidence interval (95% CI).A significant association between SLC30A8 gene 807C/T polymorphism and T2DM was found in the Chinese population under allelic (OR: 0.85, 95% CI: 0.80-0.91, P?=?7.42?×?10-7), recessive (OR: 0.52, 95% CI: 0.38-0.72, P?=?8.49?×?10-5), dominant (OR: 2.40, 95% CI: 1.68-3.41, P?=?1.30?×?10-6), homozygous (OR: 0.52, 95% CI: 0.40-0.67, P?=?2.90?×?10-7), heterozygous (OR: 0.79, 95% CI: 0.71-0.88, P?=?1.63?×?10-5), and additive genetic models (OR: 0.73, 95% CI: 0.64-0.83, P?=?7.05?×?10-7).SLC30A8 gene 807C/T polymorphism was significantly associated with an increased T2DM risk in the Chinese population. Therefore, individuals of Chinese descent with the C allele of SLC30A8 gene 807C/T polymorphism may be more susceptible to developing T2DM, while individuals with the T allele may be protected against T2DM.

SUBMITTER: Li YY

PROVIDER: S-EPMC5974095 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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Solute Carrier Family 30 Member 8 Gene 807C/T Polymorphism and Type 2 Diabetes Mellitus in the Chinese Population: A Meta-Analysis Including 6,942 Subjects.

Li Yan-Yan YY Lu Xin-Zheng XZ Wang Hui H Yang Xin-Xing XX Geng Hong-Yu HY Gong Ge G Zhan Yi-Yang YY Kim Hyun Jun HJ Yang Zhi-Jian ZJ

Frontiers in endocrinology 20180523

<h4>Background</h4>Although <i>solute carrier family 30 (zinc transporter) member 8 (SLC30A8)</i> gene 807C/T polymorphism is associated with an increased risk of type 2 diabetes mellitus (T2DM) risk, there remains some inconsistency between individual studies.<h4>Objective</h4>The aim of the study is to explore the relationship between <i>SLC30A8</i> gene 807C/T polymorphism and T2DM in the Chinese population.<h4>Methods</h4>The current meta-analysis compiles and analyzes the data of 6,942 part ...[more]

PMID: 29875737

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Dataset Information

Solute Carrier Family 30 Member 8 Gene 807C/T Polymorphism and Type 2 Diabetes Mellitus in the Chinese Population: A Meta-Analysis Including 6,942 Subjects.

Publications

Solute Carrier Family 30 Member 8 Gene 807C/T Polymorphism and Type 2 Diabetes Mellitus in the Chinese Population: A Meta-Analysis Including 6,942 Subjects.

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