Ontology highlight
ABSTRACT:
SUBMITTER: Hao Y
PROVIDER: S-EPMC5974104 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Hao Yaxing Y Wang Yifei Y Liu Xiaobing X Yang Xia X Wang Pengcheng P Tian Qin Q Bai Qiang Q Chen Xiangyu X Li Zhirong Z Wu Jialin J Xie Zhunyi Z Zhou Xinyuan X Zhou Yuyang Y Yin Zhinan Z Wu Yuzhang Y Ye Lilin L
Frontiers in immunology 20180523
Follicular helper CD4<sup>+</sup> T (T<sub>FH</sub>) cells are critical for optimal B-cell-mediated humoral immunity by initiating, fueling, and sustaining germinal center reactions. The differentiation of T<sub>FH</sub> cells relies on multiple intrinsic and extrinsic factors; however, the details by which these factors are integrated to coordinate T<sub>FH</sub> differentiation are largely unknown. In this study, using a mouse model of acute lymphocytic choriomeningitis virus (LCMV) viral infe ...[more]