Ontology highlight
ABSTRACT:
SUBMITTER: Siddiqui FA
PROVIDER: S-EPMC5974195 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Siddiqui Farid Ahmad FA Prakasam Gopinath G Chattopadhyay Shilpi S Rehman Asad Ur AU Padder Rayees Ahmad RA Ansari Mohammad Afaque MA Irshad Rasha R Mangalhara Kailash K Bamezai Rameshwar N K RNK Husain Mohammad M Ali Syed Mansoor SM Iqbal Mohammad Askandar MA
Scientific reports 20180529 1
Warburg effect is an emerging hallmark of cancer cells with pyruvate kinase M2 (PKM2) as its key regulator. Curcumin is an extensively-studied anti-cancer compound, however, its role in affecting cancer metabolism remains poorly understood. Herein, we show that curcumin inhibits glucose uptake and lactate production (Warburg effect) in a variety of cancer cell lines by down-regulating PKM2 expression, via inhibition of mTOR-HIF1α axis. Stable PKM2 silencing revealed that PKM2 is required for War ...[more]