Ontology highlight
ABSTRACT:
SUBMITTER: Uchida T
PROVIDER: S-EPMC5974230 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Uchida Takahiro T Nakashima Hiroyuki H Yamagata Akira A Ito Seigo S Ishikiriyama Takuya T Nakashima Masahiro M Seki Shuhji S Kumagai Hiroo H Oshima Naoki N
Scientific reports 20180529 1
Lupus nephritis is a crucial complication of systemic lupus erythematosus. In this study, we investigated the roles of mouse natural killer T (NKT) cells in lupus nephritis. From 24 weeks of age, NZB/NZW F1 mice were injected with alpha-galactosylceramide (α-GalCer) or vehicle once a week for four weeks. In the α-GalCer group, the levels of proteinuria and blood urea nitrogen were significantly lower than those in the vehicle group. The histological evaluation showed a decrease in glomerular imm ...[more]