Ontology highlight
ABSTRACT:
SUBMITTER: He S
PROVIDER: S-EPMC5974346 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Cell death & disease 20180529 6
Tumor repopulation during therapy is an important cause of treatment failure. Strategies to overcome repopulation are arising in parallel with advances in the comprehension of underlying biological mechanisms. Here, we reveal a new mechanism by which high mobility group box 1 (HMGB1) released by dying cells during radiotherapy or chemotherapy could stimulate living tumor cell proliferationInhibition or genetic ablation of HMGB1 suppressed tumor cell proliferation. This effect was due to binding ...[more]