Ontology highlight
ABSTRACT:
SUBMITTER: Qian G
PROVIDER: S-EPMC5974352 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Qian Gui G Lv Huifang H Lin Jihui J Li Xiaomeng X Lv Qizhuang Q Wang Tao T Zhang Jing J Dong Wang W Guo Kangkang K Zhang Yanming Y
Scientific reports 20180529 1
Classical swine fever virus (CSFV), the etiological agent of classical swine fever, causes enormous economic loss to the pig industry. Ferritin heavy chain (FHC) is a notable anti-apoptotic protein, and existing evidence suggests that CSFV cannot induce apoptosis of host cells, however, the role of FHC in CSFV replication remains unclear. In the present study, we found that recombinant lentivirus-mediated knockdown or overexpression of FHC inhibited or enhanced CSFV replication, respectively, in ...[more]