Ontology highlight
ABSTRACT:
SUBMITTER: Lim D
PROVIDER: S-EPMC5974375 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Lim Daejin D Kim Kwang Soo KS Jeong Jae-Ho JH Marques Oriana O Kim Hyun-Ju HJ Song Miryoung M Lee Tae-Hoon TH Kim Jae Il JI Choi Hueng-Sik HS Min Jung-Joon JJ Bumann Dirk D Muckenthaler Martina U MU Choy Hyon E HE
Nature communications 20180529 1
Macrophages release iron into the bloodstream via a membrane-bound iron export protein, ferroportin (FPN). The hepatic iron-regulatory hormone hepcidin controls FPN internalization and degradation in response to bacterial infection. Salmonella typhimurium can invade macrophages and proliferate in the Salmonella-containing vacuole (SCV). Hepcidin is reported to increase the mortality of Salmonella-infected animals by increasing the bacterial load in macrophages. Here we assess the iron levels and ...[more]