Ontology highlight
ABSTRACT:
SUBMITTER: He D
PROVIDER: S-EPMC5975068 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
He Dan D Zhao Mingming M Wu Congying C Zhang Wenjing W Niu Chenguang C Yu Baoqi B Jin Jingru J Ji Liang L Willard Belinda B Mathew Anna V AV Chen Y Eugene YE Pennathur Subramaniam S Yin Huiyong H He Yuan Y Pan Bing B Zheng Lemin L
Redox biology 20171208
Disruption of endothelial monolayer integrity is the primary instigating factor for many cardiovascular diseases. High density lipoprotein (HDL) oxidized by heme enzyme myeloperoxidase (MPO) is dysfunctional in promoting endothelial repair. Apolipoprotein A-1 mimetic 4F with its pleiotropic benefits has been proven effective in many in vivo models. In this study we investigated whether 4F promotes endothelial repair and restores the impaired function of oxidized HDL (Cl/NO<sub>2</sub>-HDL) in pr ...[more]