Ontology highlight
ABSTRACT:
SUBMITTER: Fu DJ
PROVIDER: S-EPMC5975277 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
European journal of medicinal chemistry 20170708
A series of 5,6-diaryl-1,2,4-triazines hybrids bearing a 1,2,3-triazole linker were synthesized by molecular hybridization strategy and evaluated for antiproliferative activity against three selected cancer cell lines (MGC-803, EC-109 and PC-3). The first structure-activity relationship (SAR) for these 5,6-diaryl-1,2,4-triazines is explored in this report with evaluation of 15 variants of the structural class. Among these chemical derivatives, 3-(((1-(4-fluorobenzyl)-1H-1,2,3-triazol-4-yl)methyl ...[more]