Targeting autophagy in cancer.
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ABSTRACT:
SUBMITTER: Levy JMM
PROVIDER: S-EPMC5975367 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Publications
Targeting autophagy in cancer.
Levy Jean M Mulcahy JMM Towers Christina G CG Thorburn Andrew A
Nature reviews. Cancer 20170728 9
Autophagy is a mechanism by which cellular material is delivered to lysosomes for degradation, leading to the basal turnover of cell components and providing energy and macromolecular precursors. Autophagy has opposing, context-dependent roles in cancer, and interventions to both stimulate and inhibit autophagy have been proposed as cancer therapies. This has led to the therapeutic targeting of autophagy in cancer to be sometimes viewed as controversial. In this Review, we suggest a way forwards ...[more]
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