Ontology highlight
ABSTRACT:
SUBMITTER: Boukouvalas A
PROVIDER: S-EPMC5975664 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Boukouvalas Alexis A Hensman James J Rattray Magnus M
Genome biology 20180529 1
High-throughput single-cell gene expression experiments can be used to uncover branching dynamics in cell populations undergoing differentiation through pseudotime methods. We develop the branching Gaussian process (BGP), a non-parametric model that is able to identify branching dynamics for individual genes and provide an estimate of branching times for each gene with an associated credible region. We demonstrate the effectiveness of our method on simulated data, a single-cell RNA-seq haematopo ...[more]