Ontology highlight
ABSTRACT:
SUBMITTER: Tsouko E
PROVIDER: S-EPMC5975720 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Tsouko Efrosini E Wang Jun J Frigo Daniel E DE Aydoğdu Eylem E Williams Cecilia C
Carcinogenesis 20150618 9
Triple-negative breast cancer (TNBC) is characterized by aggressiveness and affects 10-20% of breast cancer patients. Since TNBC lacks expression of ERα, PR and HER2, existing targeted treatments are not effective and the survival is poor. In this study, we demonstrate that the tumor suppressor microRNA miR-200a directly regulates the oncogene EPH receptor A2 (EPHA2) and modulates TNBC migration. We show that EPHA2 expression is correlated with poor survival specifically in basal-like breast can ...[more]