Ontology highlight
ABSTRACT:
SUBMITTER: Chen X
PROVIDER: S-EPMC5975960 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Chen Xiaowei X Deng Huan H Churchill Michael J MJ Luchsinger Larry L LL Du Xing X Chu Timothy H TH Friedman Richard A RA Middelhoff Moritz M Ding Hongxu H Tailor Yagnesh H YH Wang Alexander L E ALE Liu Haibo H Niu Zhengchuan Z Wang Hongshan H Jiang Zhengyu Z Renders Simon S Ho Siu-Hong SH Shah Spandan V SV Tishchenko Pavel P Chang Wenju W Swayne Theresa C TC Munteanu Laura L Califano Andrea A Takahashi Ryota R Nagar Karan K KK Renz Bernhard W BW Worthley Daniel L DL Westphalen C Benedikt CB Hayakawa Yoku Y Asfaha Samuel S Borot Florence F Lin Chyuan-Sheng CS Snoeck Hans-Willem HW Mukherjee Siddhartha S Wang Timothy C TC
Cell stem cell 20171130 6
Myeloid-biased hematopoietic stem cells (MB-HSCs) play critical roles in recovery from injury, but little is known about how they are regulated within the bone marrow niche. Here we describe an auto-/paracrine physiologic circuit that controls quiescence of MB-HSCs and hematopoietic progenitors marked by histidine decarboxylase (Hdc). Committed Hdc<sup>+</sup> myeloid cells lie in close anatomical proximity to MB-HSCs and produce histamine, which activates the H<sub>2</sub> receptor on MB-HSCs t ...[more]