Reduced bacterial skin infections in HIV-infected African children randomized to long-term cotrimoxazole prophylaxis.

ABSTRACT:

Objective

To evaluate whether cotrimoxazole prophylaxis prevents common skin conditions in HIV-infected children.

Design

Open-label randomized controlled trial of continuing versus stopping daily cotrimoxazole (post-hoc analysis).

Setting

Three sites in Uganda and one in Zimbabwe.

Participants

A total of 758 children aged more than 3 years receiving antiretroviral therapy (ART) for more than 96 weeks in the ARROW trial were randomized to stop (n = 382) or continue (n = 376) cotrimoxazole after median (interquartile range) 2.1(1.8, 2.2) years on ART.

Intervention

Continuing versus stopping daily cotrimoxazole.

Main outcome measures

Nurses screened for signs/symptoms at 6-week visits. This was a secondary analysis of ARROW trial data, with skin comp

SUBMITTER: Prendergast AJ 

PROVIDER: S-EPMC5976221 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature