Ontology highlight
ABSTRACT:
SUBMITTER: Thamban Chandrika N
PROVIDER: S-EPMC5976239 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Thamban Chandrika Nishad N Shrestha Sanjib K SK Ngo Huy X HX Tsodikov Oleg V OV Howard Kaitlind C KC Garneau-Tsodikova Sylvie S
Journal of medicinal chemistry 20171219 1
The extensive use of fluconazole (FLC) and other azole drugs has caused the emergence and rise of azole-resistant fungi. The fungistatic nature of FLC in combination with toxicity concerns have resulted in an increased demand for new azole antifungal agents. Herein, we report the synthesis and antifungal activity of novel alkylated piperazines and alkylated piperazine-azole hybrids, their time-kill studies, their hemolytic activity against murine erythrocytes, as well as their cytotoxicity again ...[more]