Identification of a peptide for folate receptor alpha by phage display and its tumor targeting activity in ovary cancer xenograft.
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ABSTRACT:
SUBMITTER: Xing L
PROVIDER: S-EPMC5976665 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Publications
Identification of a peptide for folate receptor alpha by phage display and its tumor targeting activity in ovary cancer xenograft.
Xing Lijun L Xu Yifeng Y Sun Keyong K Wang Hong H Zhang Fengguo F Zhou Zhengpin Z Zhang Juan J Zhang Fang F Caliskan Bilgen B Qiu Zheng Z Wang Min M
Scientific reports 20180530 1
The expression level of folate receptor alpha (FRα) is located highly rate in ovarian cancer though it is remained absent in normal tissues. This highly tumor restricted expression profile makes FRα a promising target for tumor therapy and diagnosis. In this research we report a FRα binding peptide C7(Met-His-Thr-Ala-Pro-Gly-Trp-Gly-Tyr-Arg-Leu-Ser) discovered by phage display and this peptide showed specific binding to FRα expressing cells by cell ELISA and flow cytometry. Tumor targeting abili ...[more]
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