Ontology highlight
ABSTRACT:
SUBMITTER: Gaspar TB
PROVIDER: S-EPMC5977181 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Gaspar Tiago Bordeira TB Sá Ana A Lopes José Manuel JM Sobrinho-Simões Manuel M Soares Paula P Vinagre João J
Genes 20180503 5
Tumour cells can adopt telomere maintenance mechanisms (TMMs) to avoid telomere shortening, an inevitable process due to successive cell divisions. In most tumour cells, telomere length (TL) is maintained by reactivation of telomerase, while a small part acquires immortality through the telomerase-independent alternative lengthening of telomeres (ALT) mechanism. In the last years, a great amount of data was generated, and different TMMs were reported and explained in detail, benefiting from geno ...[more]