Ontology highlight
ABSTRACT:
SUBMITTER: Wang X
PROVIDER: S-EPMC5977258 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Wang Xiaoli X Wang Jiao J Zhang Wenmei W Li Boye B Zhu Ying Y Hu Qin Q Yang Yishu Y Zhang Xiaoguang X Yan Hong H Zeng Yi Y
Viruses 20180516 5
Here, we report the anti-human immunodeficiency virus (HIV) potency and underlying mechanisms of a Keggin polyoxometalate (PT-1, K₆HPTi₂W<sub>10</sub>O<sub>40</sub>). Our findings showed that PT-1 exhibited highly potent effects against a diverse group of HIV type 1 (HIV-1) strains and displayed low cytotoxicity and genotoxicity. The time-addition assay revealed that PT-1 acted at an early stage of infection, and these findings were supported by the observation that PT-1 had more potency against ...[more]