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The role of ketogenic diets in the therapeutic management of adult and paediatric gliomas: a systematic review.

ABSTRACT: AIM:We performed a systematic review of the evidence for effectiveness and acceptability of different ketogenic diets (KDs) in the therapeutic management of gliomas. METHODS:The search strategy included searches of seven electronic databases. Data extraction and quality assessment were undertaken independently by two authors. RESULTS:No randomized clinical trials were identified. Six studies (n = 39) met the eligibility criteria for this review - all were case series or reports and therefore at high risk of bias. All studies reported overall or progression-free survival; however the effectiveness of KD interventions could not be established. Dietary acceptability was not reported. CONCLUSION:The effectiveness and acceptability of KDs in the management of gliomas is unknown and high quality randomized controlled trials are needed.

SUBMITTER: Martin-McGill KJ

PROVIDER: S-EPMC5977276 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature

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The role of ketogenic diets in the therapeutic management of adult and paediatric gliomas: a systematic review.

Martin-McGill Kirsty J KJ Srikandarajah Nisaharan N Marson Anthony G AG Tudur Smith Catrin C Jenkinson Michael D MD

CNS oncology 20180416 2

<h4>Aim</h4>We performed a systematic review of the evidence for effectiveness and acceptability of different ketogenic diets (KDs) in the therapeutic management of gliomas.<h4>Methods</h4>The search strategy included searches of seven electronic databases. Data extraction and quality assessment were undertaken independently by two authors.<h4>Results</h4>No randomized clinical trials were identified. Six studies (n = 39) met the eligibility criteria for this review - all were case series or rep ...[more]

PMID: 29658772

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Project description:Use of high-fat, ketogenic diets (KDs) to support physical performance has grown in popularity over recent years. While these diets enhance fat and reduce carbohydrate oxidation during exercise, the impact of a KD on physical performance remains controversial. The objective of this work was to assess the effect of KDs on physical performance compared with mixed macronutrient diets [control (CON)]. A systematic review of the literature was conducted using PubMed and Cochrane Library databases. Randomized and nonrandomized studies were included if participants were healthy (free of chronic disease), nonobese [BMI (kg/m2) <30], trained or untrained men or women consuming KD (<50 g carbohydrate/d or serum or whole-blood β-hydroxybutyrate >0.5 mmol/L) compared with CON (fat, 12-38% of total energy intake) diets for ≥14 d, followed by a physical performance test. Seventeen studies (10 parallel, 7 crossover) with 29 performance (13 endurance, 16 power or strength) outcomes were identified. Of the 13 endurance-type performance outcomes, 3 (1 time trial, 2 time-to-exhaustion) reported lower and 10 (4 time trials, 6 time-to-exhaustion) reported no difference in performance between the KD compared with CON. Of the 16 power or strength performance outcomes, 3 (1 power, 2 strength) reported lower, 11 (4 power, 7 strength) no difference, and 2 (power) enhanced performance in the KD compared with the CON. Risk of bias identified some concern of bias primarily due to studies allowing participants to self-select diet intervention groups and the inability to blind participants to the study intervention. Overall, the majority of null results across studies suggest that a KD does not have a positive or negative impact on physical performance compared with a CON diet. However, discordant results between studies may be due to multiple factors, such as the duration consuming study diets, training status, performance test, and sex differences, which will be discussed in this systematic review.

Dataset Information

The role of ketogenic diets in the therapeutic management of adult and paediatric gliomas: a systematic review.

Publications

The role of ketogenic diets in the therapeutic management of adult and paediatric gliomas: a systematic review.

Similar Datasets

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