Ontology highlight
ABSTRACT:
SUBMITTER: Gunawardhana L
PROVIDER: S-EPMC5977466 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Gunawardhana Lhanoo L Becker Michael A MA Whelton Andrew A Hunt Barbara B Castillo Majin M Saag Kenneth K
Arthritis research & therapy 20180530 1
<h4>Background</h4>Febuxostat immediate release (IR), a xanthine oxidase inhibitor, is indicated for the management of hyperuricemia in patients with gout by lowering urate levels. An extended release (XR) formulation of febuxostat was developed to provide equal or superior efficacy on urate lowering compared with the IR formulation and potentially lower the risk of treatment-initiated gout flares due to an altered pattern of drug exposure. The present study evaluated the efficacy and safety of ...[more]