Ontology highlight
ABSTRACT:
SUBMITTER: Kahen EJ
PROVIDER: S-EPMC5978249 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Kahen Elliot John EJ Brohl Andrew A Yu Diana D Welch Darcy D Cubitt Christopher L CL Lee Jae K JK Chen Yunyun Y Yoder Sean J SJ Teer Jamie K JK Zhang Yonghong O YO Wallace Margaret R MR Reed Damon R DR
Oncotarget 20180427 32
Malignant peripheral nerve sheath tumor (MPNST) is a type of soft-tissue sarcoma strongly associated with dysfunction in neurofibromin; an inhibitor of the RAS pathway. We performed high-throughput screening of an array of FDA approved and promising agents in clinical development both alone and in combination at physiologically achievable concentrations against a panel of established MPNST cell line models. We found that drugs targeting a variety of factors in the RAS pathway can effectively lea ...[more]