The Role of PPAR and Its Cross-Talk with CAR and LXR in Obesity and Atherosclerosis.
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ABSTRACT:
SUBMITTER: Xu P
PROVIDER: S-EPMC5979375 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Publications
The Role of PPAR and Its Cross-Talk with CAR and LXR in Obesity and Atherosclerosis.
Xu Pengfei P Zhai Yonggong Y Wang Jing J
International journal of molecular sciences 20180423 4
The prevalence of obesity and atherosclerosis has substantially increased worldwide over the past several decades. Peroxisome proliferator-activated receptors (PPARs), as fatty acids sensors, have been therapeutic targets in several human lipid metabolic diseases, such as obesity, atherosclerosis, diabetes, hyperlipidaemia, and non-alcoholic fatty liver disease. Constitutive androstane receptor (CAR) and liver X receptors (LXRs) were also reported as potential therapeutic targets for the treatme ...[more]
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