Ontology highlight
ABSTRACT:
SUBMITTER: Li M
PROVIDER: S-EPMC5979387 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Li Maiquan M Xu Tao T Zhou Fei F Wang Mengmeng M Song Huaxin H Xiao Xing X Lu Baiyi B
International journal of molecular sciences 20180410 4
Nuclear factor erythroid 2-related factor 2 (Nrf2) is a key transcription factor against oxidative stress and neurodegenerative disorders. Phenylethanoid glycosides (PhGs; salidroside, acteoside, isoacteoside, and echinacoside) exhibit antioxidant and neuroprotective bioactivities. This study was performed to investigate the neuroprotective effect and molecular mechanism of PhGs. PhGs pretreatment significantly suppressed H₂O₂-induced cytotoxicity in PC12 cells by triggering the nuclear transloc ...[more]