Ontology highlight
ABSTRACT:
SUBMITTER: Zuniga R
PROVIDER: S-EPMC5979529 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Zúñiga Rafael R Valenzuela Claudio C Concha Guierdy G Brown Nelson N Zúñiga Leandro L
International journal of molecular sciences 20180329 4
TASK-3 potassium channels are believed to promote proliferation and survival of cancer cells, in part, by augmenting their resistance to both hypoxia and serum deprivation. While overexpression of TASK-3 is frequently observed in cancers, the understanding of its role and regulation during tumorigenesis remains incomplete. Here, we evaluated the effect of reducing the expression of TASK-3 in MDA-MB-231 and MCF-10F human mammary epithelial cell lines through small hairpin RNA (shRNA)-mediated kno ...[more]