Ontology highlight
ABSTRACT:
SUBMITTER: Kazarian E
PROVIDER: S-EPMC5979577 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Kazarian Elizabeth E Son HyunYoung H Sapao Paulene P Li Wei W Zhang Zhibing Z Strauss Jerome F JF Teves Maria E ME
International journal of molecular sciences 20180421 4
<i>Spag17</i> encodes a protein present in the axoneme central pair complex of motile cilia and flagella. A mutation in this gene has been reported to be associated with infertility caused by defects in sperm motility. Here, we report that <i>Spag17</i> knockout mice are infertile because of a severe defect in spermatogenesis. The histological evaluation of testis sections from mutant mice revealed seminiferous tubules with spermatogenesis arrested at the spermatid stage and cell debris in the c ...[more]