Ontology highlight
ABSTRACT:
SUBMITTER: Xu Y
PROVIDER: S-EPMC5980221 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Xu Yong Y Wang Zehua Z Du Xianhong X Liu Yuan Y Song Xiaojia X Wang Tixiao T Tan Siyu S Liang Xiaohong X Gao Lifen L Ma Chunhong C
Journal of cellular and molecular medicine 20180330 6
Increased expression of T cell immunoglobulin and mucin domain-3 (Tim-3) on invariant natural killer T (iNKT) cells is reported in chronic hepatitis B virus (HBV) infection. However, whether Tim-3 regulates iNKT cells in chronic HBV condition remains unclear. In this study, our results showed that the expression of Tim-3 was up-regulated on hepatic iNKT cells from HBV-transgenic (Tg) mice or iNKT cells stimulated with α-galactosylceramide (α-Galcer). Compared with Tim-3<sup>-</sup> iNKT cells, T ...[more]