Ontology highlight
ABSTRACT:
SUBMITTER: Willmann S
PROVIDER: S-EPMC5980303 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Willmann Stefan S Zhang Liping L Frede Matthias M Kubitza Dagmar D Mueck Wolfgang W Schmidt Stephan S Solms Alexander A Yan Xiaoyu X Garmann Dirk D
CPT: pharmacometrics & systems pharmacology 20180416 5
The population pharmacokinetics (PK) of rivaroxaban have been evaluated in several population-specific models. We developed an integrated population PK model using pooled data from 4,918 patients in 7 clinical trials across all approved indications. Effects of gender, age, and weight on apparent clearance (CL/F) and apparent volume of distribution (V/F), renal function, and comedication on CL/F, and relative bioavailability as a function of dose (F) were analyzed. Virtual subpopulations for expo ...[more]