The role of Galectin-3 in modulating tumor growth and immunosuppression within the tumor microenvironment.
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ABSTRACT:
SUBMITTER: Farhad M
PROVIDER: S-EPMC5980349 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Publications
The role of Galectin-3 in modulating tumor growth and immunosuppression within the tumor microenvironment.
Farhad Mohammad M Rolig Annah S AS Redmond William L WL
Oncoimmunology 20180220 6
The efficacy of cancer immunotherapy is limited, in part, by the multitude of immunosuppressive mechanisms present within the tumor microenvironment (TME). Galectin-3 (Gal-3) is a lectin that contributes to TME immunosuppression and regulates diverse functions including cellular homeostasis and cancer biology. Increased Gal-3 expression during cancer progression augments tumor growth, invasiveness, metastatic potential, and immune suppression, which highlights the potential use of Gal-3 as a the ...[more]
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