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Hippo-yap signaling in ocular development and disease.

ABSTRACT: The Hippo-Yes associated protein (Yap) pathway plays an important role in organ size control by regulating cell proliferation, apoptosis, and stem cell renewal. Hippo-Yap signaling also functions at the level of cellular development in a variety of organs through its effects on cell cycle control, cell survival, cell polarity, and cell fate. Because of its important roles in normal development and homeostasis, abnormal regulation of this pathway has been shown to lead to pathological outcomes such as tissue overgrowth, tumor formation, and abnormal organogenesis, including ocular-specific disorders. In this review, we summarize how normal and perturbed control of Yap signaling is implicated in ocular development and disease Developmental Dynamics 247:794-806, 2018. © 2018 Wiley Periodicals, Inc.

SUBMITTER: Lee M

PROVIDER: S-EPMC5980750 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature

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Hippo-yap signaling in ocular development and disease.

Lee Matthew M Goraya Navneet N Kim Seonhee S Cho Seo-Hee SH

Developmental dynamics : an official publication of the American Association of Anatomists 20180423 6

The Hippo-Yes associated protein (Yap) pathway plays an important role in organ size control by regulating cell proliferation, apoptosis, and stem cell renewal. Hippo-Yap signaling also functions at the level of cellular development in a variety of organs through its effects on cell cycle control, cell survival, cell polarity, and cell fate. Because of its important roles in normal development and homeostasis, abnormal regulation of this pathway has been shown to lead to pathological outcomes su ...[more]

PMID: 29532607

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Hippo signaling regulates pancreas development through inactivation of Yap.

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Hippo Signaling Mediators Yap and Taz Are Required in the Epicardium for Coronary Vasculature Development.

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NOS1AP Functionally Associates with YAP To Regulate Hippo Signaling.

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| S-EPMC7834087 | biostudies-literature

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