Ontology highlight
ABSTRACT:
SUBMITTER: Biswas S
PROVIDER: S-EPMC5981611 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Biswas Soma S Li Ping P Wu Hongguang H Shafiquzzaman Md M Murakami Shunichi S Schneider Michael D MD Mishina Yuji Y Li Baojie B Li Jing J
Scientific reports 20180531 1
Bone morphogenetic proteins (BMPs) activate the canonical Smad1/5/8 and non-canonical Tak1-MAPK pathways via BMP receptors I and II to regulate skeletal development and bone remodeling. Specific ablation of Bmpr1a in immature osteoblasts, osteoblasts, or osteocytes results in an increase in cancellous bone mass, yet opposite results have been reported regarding the underlying mechanisms. Moreover, the role for BMPRIA-mediated signaling in bone marrow mesenchymal stromal cells (BM-MSCs) has not b ...[more]