Ontology highlight
ABSTRACT:
SUBMITTER: Liu L
PROVIDER: S-EPMC5981615 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Liu Lei L Chen Xiujie X Hu Chunyu C Zhang Denan D Shao Zhuo Z Jin Qing Q Yang Jingbo J Xie Hongbo H Liu Bo B Hu Ming M Ke Kehui K
Scientific reports 20180531 1
Chemotherapy agents can cause serious adverse effects by attacking both cancer tissues and normal tissues. Therefore, we proposed a synthetic lethality (SL) concept-based computational method to identify specific anticancer drug targets. First, a 3-step screening strategy (network-based, frequency-based and function-based screening) was proposed to identify the SL gene pairs by mining 697 cancer genes and the human signaling network, which had 6306 proteins and 62937 protein-protein interactions ...[more]