Ontology highlight
ABSTRACT:
SUBMITTER: Hernandez-Doria JD
PROVIDER: S-EPMC5982111 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Hernandez-Doria Juan D JD Sperandio Vanessa V
Cell host & microbe 20180501 5
Bacteriophage-encoded genetic elements control bacterial biological functions. Enterohemorrhagic Escherichia coli (EHEC) strains harbor lambda-phages encoding the Shiga-toxin (Stx), which is expressed during the phage lytic cycle and associated with exacerbated disease. Phages also reside dormant within bacterial chromosomes through their lysogenic cycle, but how this impacts EHEC virulence remains unknown. We find that during lysogeny the phage transcription factor Cro activates the EHEC type I ...[more]