The Immune Landscape of Cancer.
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ABSTRACT:
SUBMITTER: Thorsson V
PROVIDER: S-EPMC5982584 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Publications
The Immune Landscape of Cancer.
Thorsson Vésteinn V Gibbs David L DL Brown Scott D SD Wolf Denise D Bortone Dante S DS Ou Yang Tai-Hsien TH Porta-Pardo Eduard E Gao Galen F GF Plaisier Christopher L CL Eddy James A JA Ziv Elad E Culhane Aedin C AC Paull Evan O EO Sivakumar I K Ashok IKA Gentles Andrew J AJ Malhotra Raunaq R Farshidfar Farshad F Colaprico Antonio A Parker Joel S JS Mose Lisle E LE Vo Nam Sy NS Liu Jianfang J Liu Yuexin Y Rader Janet J Dhankani Varsha V Reynolds Sheila M SM Bowlby Reanne R Califano Andrea A Cherniack Andrew D AD Anastassiou Dimitris D Bedognetti Davide D Mokrab Younes Y Newman Aaron M AM Rao Arvind A Chen Ken K Krasnitz Alexander A Hu Hai H Malta Tathiane M TM Noushmehr Houtan H Pedamallu Chandra Sekhar CS Bullman Susan S Ojesina Akinyemi I AI Lamb Andrew A Zhou Wanding W Shen Hui H Choueiri Toni K TK Weinstein John N JN Guinney Justin J Saltz Joel J Holt Robert A RA Rabkin Charles S CS Lazar Alexander J AJ Serody Jonathan S JS Demicco Elizabeth G EG Disis Mary L ML Vincent Benjamin G BG Shmulevich Ilya I
Immunity 20180405 4
We performed an extensive immunogenomic analysis of more than 10,000 tumors comprising 33 diverse cancer types by utilizing data compiled by TCGA. Across cancer types, we identified six immune subtypes-wound healing, IFN-γ dominant, inflammatory, lymphocyte depleted, immunologically quiet, and TGF-β dominant-characterized by differences in macrophage or lymphocyte signatures, Th1:Th2 cell ratio, extent of intratumoral heterogeneity, aneuploidy, extent of neoantigen load, overall cell proliferati ...[more]
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