Ontology highlight
ABSTRACT:
SUBMITTER: Santinon G
PROVIDER: S-EPMC5983219 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Santinon Giulia G Brian Irene I Pocaterra Arianna A Romani Patrizia P Franzolin Elisa E Rampazzo Chiara C Bicciato Silvio S Dupont Sirio S
The EMBO journal 20180412 11
YAP/TAZ, downstream transducers of the Hippo pathway, are powerful regulators of cancer growth. How these factors control proliferation remains poorly defined. Here, we found that YAP/TAZ directly regulate expression of key enzymes involved in deoxynucleotide biosynthesis and maintain dNTP precursor pools in human cancer cells. Regulation of deoxynucleotide metabolism is required for YAP-induced cell growth and underlies the resistance of YAP-addicted cells to chemotherapeutics targeting dNTP sy ...[more]